HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
Function:
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity).
Subcellular Location:
Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution.
Tissue Specificity:
Expressed in brain and testis and detected in heart and placenta.[DEVELOPMENTAL STAGE] Expressed in fetal brain.
Similarity:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 7 RCC1 repeats.
SWISS:
Q5GLZ8
Gene ID:
26091
Database links:
Entrez Gene: 26091 Human
Entrez Gene: 67345 Mouse
Omim: 609248 Human
SwissProt: Q5GLZ8 Human
SwissProt: Q6PAV2 Mouse
Unigene: 51891 Human
Unigene: 234437 Mouse
Unigene: 441725 Mouse
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