Rabbit Anti-ERVFRD-1 antibody

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SYCY2_HUMAN; EFRD1_HUMAN; Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; TM; SU; ERVFRD-1; ERVFRDE1; UNQ6191/PRO20218;

Cat:

SL15466R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human HERV-FRD :331-430/538

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HISLV1 or SISLV1 virions and confer infectivity.
SU mediates receptor recognition (By similarity).
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

Subunit:
The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

Subcellular Location:
Virion.
Transmembrane protein: Cell membrane; Single-pass membrane protein (Potential).

Tissue Specificity:
Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Post-translational modifications:
Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity).
The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).

Similarity:
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.

SWISS:
P60508

Gene ID:
2086

Database links:

Entrez Gene: 2086 Human

SwissProt: P60508 Human

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