Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HISLC2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HISLC2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HISLC2 is highly expressed in cerebellum and is localized to the nucleus in cells. HISLC2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HISLC2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HISLC2 could possess tumor suppressor capabilities.
Function:
Transcriptional repressor.
Subunit:
Self-associates. Interacts with HIC1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highest levels in cerebellum.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Contains 1 BTB (POZ) domain.
Contains 5 C2H2-type zinc fingers.
SWISS:
Q96JB3
Gene ID:
23119
Database links:
Entrez Gene: 23119 Human
Omim: 607712 Human
SwissProt: Q96JB3 Human
Unigene: 632767 Human
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