Rabbit Anti-FGFR substrate 3 antibody

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FGFR signalling adaptor SNT2; FGFR substrate 3; Fibroblast growth factor receptor substrate 3; FRS2 beta; FRS2B; FRS3; FRS3 protein; MGC17167; SNT 2; Suc1 associated neurotrophic factor target 2 (FGFR signalling adaptor); Suc1 associated neurotrophic fact

Cat:

SL10383R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FGFR substrate 3:401-492/492

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq, Jul 2008].

Function:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Subunit:
Binds NTRK1. Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by SFGF or NGFB.

Similarity:
Contains 1 IRS-type PTB domain.

SWISS:
O43559

Gene ID:
10817

Database links:

Entrez Gene: 10817 Human

Entrez Gene: 107971 Mouse

Entrez Gene: 316213 Rat

Omim: 607744 Human

SwissProt: O43559 Human

SwissProt: Q91WJ0 Mouse

SwissProt: Q52RG8 Rat

Unigene: 194208 Human

Unigene: 34398 Rat

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