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Rabbit Anti-GGT5 light chain antibody
g-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of Glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts Leukotriene C4 to Leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and tissues there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
Subunit:
Heterodimer composed of the light and heavy chains. The active site is located in the light chain
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Similarity:
Belongs to the gamma-glutamyltransferase family.
SWISS:
P36269
Gene ID:
2687
Database links:
Entrez Gene: 2687 Human
Entrez Gene: 23887 Mouse
Entrez Gene: 29566 Rat
Omim: 137168 Human
SwissProt: P36269 Human
SwissProt: Q9Z2A9 Mouse
SwissProt: Q9QWE9 Rat
Unigene: 437156 Human
Unigene: 257927 Mouse
Unigene: 44367 Rat
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