The Myc-associated zinc finger protein MAZ is a transcription factor that participates in both the initiation and termination of transcription of target genes. MAZ functions as a true transcriptional repressor in that it represses transcription independent of the c-Myc promoter. Both MAZ and SP1 bind to the parathyroid hormone (PTH)/ PTH-related peptide receptor promoter, thereby influencing the cell-specific expression of its gene product. MAZ and SP1 also regulate expression from the serotonin 1A receptor gene promoter, suggesting that MAZ may act on a variety of promoters through G-C rich sequences, which serve as binding sites for the SP1 family of transcription factors. Competition between SP1 and MAZ control tissue-specific expression of the PNMT gene. The interaction of MAZ with the transcriptional repressor FAC1 may affect gene regulation in neurodegeneration. MAZ also acts as a growth suppressor protein, in part by affecting the levels of key cell cycle regulatory proteins such as cyclin A and E.
Function:
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/SLCrich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
Subunit:
Interacts with BPTF.
Subcellular Location:
Nucleus (Probable). Note=In brains of Alzheimer disease patients, present in a plaque-like structures.
Tissue Specificity:
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).
Similarity:
Contains 6 C2H2-type zinc fingers.
SWISS:
P56270
Gene ID:
4150
Database links:
Entrez Gene: 4150 Human
Entrez Gene: 17188 Mouse
Entrez Gene: 691842 Rat
Omim: 600999 Human
SwissProt: P56270 Human
SwissProt: P56671 Mouse
Unigene: 23650 Human
Unigene: 378964 Mouse
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