SLAIN1 is a 561 amino acid member of the SLAIN motif-containing family and is expressed in embryonic stem cells, as well as in lung, brain and testis, where it exists as two alternatively spliced isoforms. The gene encoding SLAIN1 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
Tissue Specificity:
Expressed in embryonic stem cells.
Similarity:
Belongs to the SLAIN motif-containing family.
SWISS:
Q8ND83
Gene ID:
122060
Database links:
Entrez Gene: 122060 Human
Omim: 610491 Human
SwissProt: Q8ND83 Human
Unigene: 349955 Human
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