Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFⅹB expression, thereby inhibiting NFⅹB-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 96 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Function:
BCL6B acts as a sequence-specific transcriptional repressor in association with BCL6. It may function in a narrow stage or be related to some events in the early B-cell development.
Subcellular Location:
Nuclear
Tissue Specificity:
Ubiquitously expressed with higher expression found in heart and placenta.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 5 C2H2-type zinc fingers.
SWISS:
Q8N143
Gene ID:
255788
Database links:
Entrez Gene: 255877 Human
Omim: 608992 Human
SwissProt: Q8N143 Human
Unigene: 22575 Human
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