This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]
Function:
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Tissue Specificity:
Isoform 2 expression is enhanced in testis.
Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 3 IQ domains.
Contains 1 Ras-GAP domain.
Contains 1 WW domain.
SWISS:
Q13576
Gene ID:
10788
Database links:
Entrez Gene: 10788 Human
Entrez Gene: 544963 Mouse
Omim: 605401 Human
SwissProt: Q13576 Human
SwissProt: Q3UQ44 Mouse
Unigene: 291030 Human
Unigene: 38878 Mouse
Unigene: 38878 Mouse
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