A variety of morphological and molecular changes are required for mature spermatozoa formation. These steps are temporally guided by the transcription and translation of several testis-specific genes. SPANX (sperm protein associated with the nucleus, X-linked) family members are sperm- and testis-specific proteins containing between 97-103 amino acids, whose genes form a cluster on chromosome X. Sharing a high level of sequence similarity, SPANX-A, -B, -C, -D and -E localize to both cytoplasm and nucleus where they are associated with nuclear craters. SPANX-B (Sperm protein associated with the nucleus on the X chromosome B/F) is a 103 amino acid protein that is detected in round and elongating spermatids.
Subcellular Location:
Cytoplasm. Nucleus. Associated with nuclear craters.
Tissue Specificity:
Detected in testis and sperm.
Similarity:
Belongs to the SPAN-X family.
SWISS:
Q9NS25
Gene ID:
71490
Database links:
Entrez Gene: 171490 Human
Entrez Gene: 100133171 Human
Entrez Gene: 728695 Human
Omim: 300669 Human
SwissProt: Q9NS25 Human
Unigene: 434105 Human
Unigene: 711489 Human
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