Pinch is a focal adhesion protein that is a component of the ILK-PINCH complex. This complex is a major part of the growth factor and integrin signaling pathway. Pinch is involved in cell differentiation, proliferation and survival by acting as an effector of integrin and growth factor signaling. It is a cytoplasmic protein expressed in most tissues and consists of five LIM domains, a nuclear localization signal and a nuclear export signal. The PINCH-1/ILK complex is regulated by another member of the Pinch family, PINCH-2, which also forms a complex with ILK.
Function:
Pinch is a focal adhesion protein that is a component of the ILK-PINCH complex. This complex is a major part of the growth factor and integrin signaling pathway. Pinch is involved in cell differentiation, proliferation and survival by acting as an effector of integrin and growth factor signaling. It is a cytoplasmic protein expressed in most tissues and consists of five LIM domains, a nuclear localization signal and a nuclear export signal. The PINCH-1/ILK complex is regulated by another member of the Pinch family, PINCH-2, which also forms a complex with ILK.
Subcellular Location:
Nucleus. Cell junction > focal adhesion. Cell membrane.
Similarity:
Contains 5 LIM zinc-binding domains.
SWISS:
Q7Z4I7
Gene ID:
55679
Database links:
Entrez Gene: 55679 Human
Entrez Gene: 225341 Mouse
Entrez Gene: 361303 Rat
Omim: 607908 Human
SwissProt: Q7Z4I7 Human
SwissProt: Q91XD2 Mouse
Unigene: 469881 Human
Unigene: 24551 Mouse
Unigene: 115282 Rat
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