Cas/HEF1 associated signal transducer;
CHAT;
FLJ39664;
Novel SH2 containing protein 3;
Novel SH2-containing protein 3;
NSP 3;
PRO34088;
SH2 domain containing 3C;
SH2 domain containing Eph receptor binding protein 1;
SH2 domain containing protein
Cat:
SL13657R
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Cow,)
Immunogen：
KLH conjugated synthetic peptide derived from human NSP3:761-860/860
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).
Function: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.
Subcellular Location: Cytoplasm. Membrane. Associated with the membrane when EGF-stimulated. Found at ruffling membranes.
Specific References (1) | SL13657R has been referenced in 1 publications.
[IF=2.401] Jie Wang . et al. BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice. Neurol Res. 2021;43(3):199-209 IF ; Human.
