Home
>
Product
>
Antibody
>
Rabbit Anti-phospho-SLP76 (Tyr145) antibody
The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.
Function:
Involved in T-cell antigen receptor mediated signaling.
Subunit:
Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
Post-translational modifications : Phosphorylated after T-cell receptor activation by ZAP-70.
Similarity:
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 SH2 domain.
SWISS:
Q13094
Gene ID:
3937
Database links:
Entrez Gene: 3937 Human
Omim: 601603 Human
SwissProt: Q13094 Human
Unigene: 304475 Human
|
|