BKS;
Breast tumor kinase substrate;
BRK substrate;
Signal transducing adaptor protein 2;
Signal-transducing adaptor protein 2;
Ssignal transducing adaptor family member 2;
STAP 2;
STAP-2;
STAP2;
STAP2_HUMAN.
Cat:
SL13667R
Species Reactivity：
(predicted: Human,)
Immunogen：
KLH conjugated synthetic peptide derived from human STAP2:151-250/403
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues (1,2). Kinases are capable of influencing the oncogenic potential of cell sytems at the level of oncoprotein or tumor suppressor protein phosphorylation states (1,2). STAP-2 is a protein that contains a pleckstrin homology (PH) domain and an SH2 domain, and associates with BRK (3). BRK (breast tumor kinase, Sik) is a 451 amino acid, nonreceptor protein-tyrosine kinase that is overexpressed in breast tumors and metastatic melanoma cell lines (4). Similar to the Src family of intracellular kinses, BRK is comprised of an SH3 domain, an SH2 domain, and a catalytic domain (5). STAP-2 is susceptiple to tyrosine phosphorylation and may be invovled in tyrosine kinase-mediated signaling cascades, whose aberrant function may lead to metastis (3).
Function: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
Subunit: Interacts with PTK6 and CSF1R.
Subcellular Location: Cytoplasm.
Tissue Specificity: Widely expressed.
Post-translational modifications: Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.
Specific References (1) | SL13667R has been referenced in 1 publications.
[IF=2.32] Xu, Shouyu, et al. "Transcriptional profiling of rat skeletal muscle hypertrophy under restriction of blood flow." Gene (2016). IHSLCP ; Rat.
