Transmembrane proteins contain transmembrane domains that are usually characterized by alpha-helical structures. Transmembrane proteins exist as thermodynamically stable hetero- and homodimers that interact with the lipid bilayer and are involved in both material exchange and communication between the cell and the environment. PL6 is a 351 amino acid multi-pass membrane protein that is highly expressed in kidney and skeletal muscle with lower levels of expression detected in liver, placenta, prancreas, lung, heart and brain. PL6 contains one phosphoserine residue and several transmembrane domains, suggesting that it may participate in protein exchange and signaling events between cells.
Function:
PL6 is an integral membrane protein with signal transduction activity.
Subcellular Location:
Membrane; Multi-pass membrane protein
SWISS:
Q12893
Gene ID:
11070
Database links:
Entrez Gene: 11070 Human
Entrez Gene: 532459 Cow
Entrez Gene: 56395 Mouse
NCBI: 5902022 Human
SwissProt: A4FUB8 Cow
SwissProt: Q12893 Human
SwissProt: Q9WUH1 Mouse
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