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Rabbit Anti-TIN-Ag antibody
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaSLVbeta3. This is a non catalytic peptidase C1 family protein.
Function:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaSLVbeta3. This is a non catalytic peptidase C1 family protein.
Subcellular Location:
Secreted; extracellular space; extracellular matrix; basement membrane.
Tissue Specificity:
Expressed in the kidney cortex, small intestine and cornea.
Post-translational modifications:
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
DISEASE:
Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.
Similarity:
Belongs to the peptidase C1 family.
Contains 1 SMB (somatomedin-B) domain.
SWISS:
Q9UJW2
Gene ID:
27283
Database links:
Entrez Gene: 27283 Human
Omim: 606749 Human
SwissProt: Q9UJW2 Human
Unigene: 127011 Human
肾小管间质性肾炎抗原(tubulointerstitial nephritis antigen,TINag)是一种主要表达在肾脏近曲小管基底膜,少部分表达在远端小管和鲍曼囊以及肠黏膜基底膜的膜糖蛋白,TINag与Ⅳ型胶原蛋白和层粘连蛋白等细胞外基质具有较高的亲和力,对维持小管基底膜的结构与功能具有重要作用.
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