Home
>
Product
>
Antibody
>
Rabbit Anti-FAM48A antibody
FAM48A is a 779 amino acid protein that interacts with p38 MAP kinase. Specifically, FAM48A and p38 are required for downregulation of E-cadherin during gastrulation. In adult tissues, FAM48A is highly expressed in testis and moderately expressed in brain and pituitary gland. It is also expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression of FAM48A has been shown to be downregulated in malignant prostate tissues. The gene encoding FAM48A maps to human chromosome 13, which houses over 400 genes and comprises approximately 4% of the human genome. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene.
Function:
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by Fgf signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.
Similarity:
Belongs to the FAM48 family.
SWISS:
Q8NEM7
Gene ID:
55578
Database links:
Entrez Gene: 55578 Human
Entrez Gene: 534126 Cow
Entrez Gene: 56790 Mouse
Entrez Gene: 361946 Rat
Omim: 613417 Human
SwissProt: Q8NEM7 Human
SwissProt: Q7TT00 Mouse
SwissProt: Q66HC7 Rat
|
|
