DCL-1 is a 232 amino acid single-pass type I membrane protein involved in endocytosis, phagocytosis and cell adhesion and migration. A SLCtype lectin receptor, DCL-1 is widely expressed with highest levels found in peripheral blood, myeloid and B lymphoid cell lines, liver, ovary and lung. DCL-1 undergoes alternative splicing to produce three isoforms designated DCL-1 isoform 1, isoform 2 (also known as fusion protein variant V34-2) and isoform 3 (also designated fusion protein variant V33-2). DCL-1 isoforms 2 and 3 are produced in malignant lympoma cells, known as Hodgkin and Reed-Sternberg (HRS) cells. DCL-1 contains one SLCtype lectin domain and is encoded by a gene that maps to human chromosome 2q24.2. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
Expressed in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
Subcellular Location:
Membrane.
Similarity:
Contains 1 SLCtype lectin domain.
SWISS:
Q8IX05
Gene ID:
9936
Database links:
Entrez Gene: 9936 Human
Entrez Gene: 66205 Mouse
Entrez Gene: 295629 Rat
Omim: 612246 Human
SwissProt: Q8IX05 Human
SwissProt: Q9DCG2 Mouse
SwissProt: Q5FVR3 Rat
Unigene: 130014 Human
Unigene: 674903 Human
Unigene: 227281 Mouse
Unigene: 98436 Rat
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