As a regulator of transcription via chromatin remodeling, p300 is a histone acetyltransferase that binds to adenovirus E1A protein and may play a role in its transforming capacity. EID-2 (EP300-interacting inhibitor of differentiation 2), also known as CREBBP/EP300 inhibitor 2, is a 236 amino acid nuclear protein that cooperates with EID-2B to bind to the SLCterminus of p300 to inhibit its activity. It also represses MYOD-dependent transcription and muscle differentiation. By interacting with SMAD2, SMAD3 and SMAD4, EID-2 selectively blocks the formation of TGFB-induced SMAD3-SMAD4 complex, thereby repressing TGFB/SMAD3-dependent signaling. Though it is abundantly expressed in placenta, EID-2 is highly expressed in skeletal muscle, heart, liver, brain and kidney. There are two isoforms of EID-2 that are produced as a result of alternative splicing events.
Function:
Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
Subcellular Location:
Nucleus.
Tissue Specificity:
Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney.
SWISS:
Q8N6I1
Gene ID:
163126
Database links:
Entrez Gene: 163126 Human
Entrez Gene: 386655 Mouse
Omim: 609773 Human
SwissProt: Q8N6I1 Human
SwissProt: Q6X7S9 Mouse
Unigene: 18949 Human
Unigene: 258201 Mouse
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