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Rabbit Anti-ITGA11 antibody
Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits, which heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen (COL) and Vitronectin. Certain Integrins can also bind to soluble ligands, such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to cellular aggregation. Integrin ?1, also known as ITGA11 or MSTP018, is a 1,189 amino acid single-pass type I membrane protein that contains one VWFA domain and seven FG-GAP repeats. Expressed at high levels in heart and uterus and present at lower levels in pancreas, kidney, skeletal muscle, placenta, lung, colon and brain, Integrin alpha 11 exists as a heterodimer with Integrin beta1 and functions as a receptor for collagen.
Function:
Integrin alpha-11/beta-1 is a receptor for collagen.
Subcellular Location:
Membrane.
Tissue Specificity:
According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.
Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
SWISS:
Q9UKX5
Gene ID:
22801
Database links:
Entrez Gene: 22801 Human
Entrez Gene: 31996 Mouse
Omim: 604789 Human
SwissProt: Q9UKX5 Human
SwissProt: P61622 Mouse
Unigene: 436416 Human
Unigene: 34883 Mouse
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