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Rabbit Anti-phospho-C5R1 (Ser338) antibody
CD88, also known as C5a receptor (C5aR), is a G protein-coupled integral membrane protein. CD88, which is expressed on neutrophils, monocytes, macrophages, hepatocytes and mast cells, as well as on various epithelial and endothelial cells, serves as a receptor for the inflammatory peptide C5a. Research studies suggest a role for CD88 in the inflammatory response. The binding of C5a to CD88 has been shown to elicit increased production of acute phase proteins in liver. In brain, an increased production of CD88 has been shown to be associated with inflammation. Research also indicates a role for C5a/C5aR in the pathogenesis of rheumatoid arthritis, as well as a heightened responsiveness of human bronchial epithelial cells (HBECs) to C5a upon exposure of these cells to cigarette smoke and other environmental irritants.
Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular Location:
Cell membrane.
Post-translational modifications:
Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P21730
Gene ID:
728
Database links:
Entrez Gene: 728 Human
Entrez Gene: 12273 Mouse
Omim: 113995 Human
SwissProt: P21730 Human
SwissProt: P30993 Mouse
SissProt: Q3TZ86 Mouse
Unigene: 2161 Human
Unigene: 247623 Mouse
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