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Rabbit Anti-CEACAM7 antibody
Carcinoembryonic antigen (CEA) is one of the most commonly used tumor markers in serum immunoassay determinations of carcinoma. Members of the CEA family contain a single N domain, with structural homology to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. CEACAM7, also referred to as CEA gene-family member 2 (CGM2), is a member of the CEA family that is expressed in normal colorectal epithelia but is downregulated in colorectal cancers, suggesting that it may play a role in tumorigenesis. CECAM7 is expressed on the apical surface of highly differentiated epithelial cells in the colorectal mucosa as well as on isolated ductal epithelial cells within the pancreas. CECAM7 may play an important role in epithelial-microbial interactions. CD66a, a biliary glycoprotein, interacts with CEACAM7.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Strongly down-regulated in colonic adenocarcinomas.
Similarity:
Belongs to the immunoglobulin superfamily. CEA family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
SWISS:
Q14002
Gene ID:
1087
Database links:
Entrez Gene: 1087 Human
SwissProt: Q14002 Human
Unigene: 74466 Human
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