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Rabbit Anti-Phospho-CEBP beta (Thr188 + Thr235) antibody
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP alpha, CEBP delta, and CEBP gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL1 response element in the IL6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
Function:
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed at low levels in the lung, kidney and spleen.
Post-translational modifications:
Sumoylated by polymeric chains of SUMO2 or SUMO3.
Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.
SWISS:
P17676
Gene ID:
1051
Database links:
Entrez Gene: 1051 Human
Entrez Gene: 12608 Mouse
Entrez Gene: 24253 Rat
Omim: 189965 Human
SwissProt: P17676 Human
SwissProt: P28033 Mouse
SwissProt: P21272 Rat
Unigene: 517106 Human
Unigene: 719041 Human
Unigene: 720603 Human
Unigene: 439656 Mouse
Unigene: 6479 Rat
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