The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Function:
C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.
Subcellular Location:
Nucleus.
Tissue Specificity:
Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.
Post-translational modifications:
Phosphorylated.
Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.
SWISS:
Q15744
Gene ID:
1053
Database links:
Entrez Gene: 1053 Human
Entrez Gene: 110794 Mouse
Entrez Gene: 25410 Rat
Omim: 600749 Human
SwissProt: Q15744 Human
SwissProt: Q6PZD9 Mouse
SwissProt: P56261 Rat
Unigene: 558308 Human
Unigene: 236223 Mouse
Unigene: 44462 Rat
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