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Rabbit Anti-CENPBD1 antibody
CENPBD1 is a 187 amino acid nuclear protein that contains one HTH CENPB-type DNA-binding domain and a HTH psq-type DNA-binding domain. The gene encoding CENPBD1 maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 HTH CENPB-type DNA-binding domain.
Contains 1 HTH psq-type DNA-binding domain.
SWISS:
B2RD01
Gene ID:
92806
Database links:
Entrez Gene: 92806 Human
SwissProt: B2RD01 Human
Unigene: 513832 Human
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