The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. [provided by RefSeq, Jul 2008]
Function:
CENPI is a constitutive protein of the knetochore that shares limited similarity with Mis6 of S. pombe. The kinetochore is a macromolecular complex located at the centromere of chromosomes and provides essential functions for chromosome segregration. CENPI is required for the localization of CENPF and the checkpoint proteins MAD1 and MAD2 to the kinetochore.
Subcellular Location:
Cytoplasmic and Nuclear
Post-translational modifications:
Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.
Similarity:
Belongs to the mis6 family.
SWISS:
Q92674
Gene ID:
2491
Database links:
Entrez Gene: 2491 Human
Omim: 300065 Human
SwissProt: Q92674 Human
Unigene: 348920 Human
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