The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins mainly regulate membrane traffic. ACAP2 is a member of the centaurin GTPase-activating protein (GAP) family, which comprises a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. ACAP1 and ACAP2 are both widely expressed in peripheral, tubular membranes and usually interact with each other in various tissues. GAP activity of both ACAP1 and ACAP2 is dependent upon phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]. ACAP2 associates with ARF1 and ARF6. Overexpression of ACAP2 blocks the formation of ARF6-dependent protrusions. K1L is a protein required for growth of the Vaccinia Virus that interacts with the ankyrin repeats of ACAP2.
Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
Tissue Specificity:
Widely expressed. Highest level in lung.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.
Contains 1 BAR domain.
Contains 1 PH domain.
SWISS:
Q15057
Gene ID:
23527
Database links:
Entrez Gene: 23527 Human
Entrez Gene: 78618 Mouse
Entrez Gene: 619382 Rat
GenBank: NM_030138 Mouse
GenBank: NM_001034006 Rat
Omim: 607766 Human
SwissProt: Q15057 Human
SwissProt: Q3UHL4 Mouse
SwissProt: Q6ZQK5 Mouse
SwissProt: Q5FVC7 Rat
Unigene: 478746 Human
Unigene: 593373 Human
Unigene: 274646 Mouse
Unigene: 208307 Rat
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