This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Subcellular Location:
Endoplasmic reticulum lumen.
Tissue Specificity:
Expressed in liver, colon and small intestine.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the type-B carboxylesterase/lipase family.
SWISS:
Q6UWW8
Gene ID:
23491
Database links:
Entrez Gene: 23491 Human
Omim: 605279 Human
SwissProt: Q6UWW8 Human
Unigene: 268700 Human
羧酸酯酶主要位于肝、其他组织及细胞胞液、线粒体和内质网。
是一种多聚蛋白，主要催化酯、硫酸酯和酰胺的水解
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