This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]
Function:
Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed by the liver and secreted in plasma.
Post-translational modifications:
Glycosylated.
Similarity:
Contains 5 Sushi (CCP/SCR) domains.
SWISS:
Q92496
Gene ID:
10877
Database links:
Entrez Gene: 10877 Human
Omim: 605337 Human
SwissProt: Q92496 Human
Unigene: 710100 Human
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