Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).[supplied by OMIM, Mar 2008]
Function:
Transcriptional activator that exhibits a unique DNA binding specificity for [AC]CpG[AC] unmethylated CpG motifs.
Subcellular Location:
Nucleus speckle. Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
May be regulated by proteolysis.
Similarity:
Contains 1 CXXSLCtype zinc finger.
Contains 1 PHD-type zinc finger.
SWISS:
Q9P0U4
Gene ID:
30827
Database links:
Entrez Gene: 30827 Human
Entrez Gene: 74322 Mouse
Entrez Gene: 29188 Rat
Omim: 609150 Human
SwissProt: Q9P0U4 Human
SwissProt: Q9CWW7 Mouse
SwissProt: A1A5S2 Rat
Unigene: 36933 Human
Unigene: 17537 Mouse
Unigene: 86349 Rat
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