CHAD is implicated in the adhesion of fibroblasts, osteoblasts and chondrocytes, which is mediated by interactions with Integrin α2/β1. Existing primarily in monomeric form, CHAD is a secreted protein that localizes to the extracellular matrix and belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily. CHADL (Chondroadherin-like protein) is a 762 amino acid protein containing 21 LRR (leucine-rich) repeats, which promote protein-ligand interactions. Chondroadherin, a closely related protein, promotes attachment of chrondocytes, osteoblasts and fibroblasts and also plays an important role in the regulation of chrodrocyte proliferation and growth. CHADL is a secreted protein that is located in the extracellular space. There are two isoforms of CHADL that exist as a result of alternative splicing events.
Function:
Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation.
Subcellular Location:
Secreted; extracellular space; extracellular matrix.
Tissue Specificity:
Present in chondrocytes at all ages.
Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
SWISS:
O15335
Gene ID:
1101
Database links:
Entrez Gene: 1101 Human
Entrez Gene: 281069 Cow
Entrez Gene: 609296 Dog
Entrez Gene: 12643 Mouse
Entrez Gene: 29195 Rat
Omim: 602178 Human
SwissProt: Q27972 Cow
SwissProt: O15335 Human
SwissProt: O55226 Mouse
SwissProt: O70210 Rat
Unigene: 97220 Human
Unigene: 88523 Mouse
Unigene: 9899 Rat
|
|
