Members of the small leucine-rich proteoglycan (SLRP) family are mostly extracellular proteins that function upstream of multiple signaling cascades. They affect intracellular phosphorylation and modulate distinct pathways, such as those driven by Toll-like receptors, TGF∫ and receptor tyrosine kinases. As a member of the SLRP family, CHADL (Chondroadherin-like protein) is a 762 amino acid protein containing 21 LRR (leucine-rich) repeats, which promote protein-ligand interactions. Chondroadherin, a closely related protein, promotes attachment of chrondocytes, osteoblasts and fibroblasts and also plays an important role in the regulation of chrodrocyte proliferation and growth. CHADL is a secreted protein that is located in the extracellular space. There are two isoforms of CHADL that exist as a result of alternative splicing events.
Subcellular Location:
Secreted; extracellular space; extracellular matrix.
Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Contains 19 LRR (leucine-rich) repeats.
Contains 2 LRRCT domains.
Contains 2 LRRNT domains.
SWISS:
Q6NUI6
Gene ID:
150356
Database links:
Entrez Gene: 150356 Human
SwissProt: Q6NUI6 Human
Unigene: 344488 Human
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