In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessiblity to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Chromatin structure alteration may be brought about by the action of ATP-dependent multiprotein complexes. One such complex is the mSin3 corepressor complex, which contains mSin3, the histone deacetylases HDAC1 and HDAC2, the associated proteins SAP 30 and SAP 18, and the autoantigens Mi2-a and Mi2-b.
Function:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Subcellular Location:
Nucleus. Cytoplasm > cytoskeleton > centrosome. Associates with centrosomes in interphase and mitosis.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Contains 2 PHD-type zinc fingers.
SWISS:
Q12873
Gene ID:
1107
Database links:
Entrez Gene: 455278 Chimpanzee
Entrez Gene: 1107 Human
Entrez Gene: 216848 Mouse
Entrez Gene: 303241 Rat
Omim: 602120 Human
SwissProt: Q12873 Human
Unigene: 25601 Human
Unigene: 178246 Mouse
Unigene: 23882 Rat
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