The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008]
Function:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
Subcellular Location:
Nucleus. Cytoplasm > cytoskeleton > centrosome. Associates with centrosomes in interphase.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Contains 2 PHD-type zinc fingers.
SWISS:
Q14839
Gene ID:
1108
Database links:
Entrez Gene: 1108 Human
Entrez Gene: 107932 Mouse
Omim: 603277 Human
SwissProt: Q14839 Human
SwissProt: Q6PDQ2 Mouse
Unigene: 162233 Human
Unigene: 333388 Mouse
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