CHD6 is a 2,715 amino acid protein encoded by the human gene CHD6. CHD6 belongs to the Snf2/Rad54 helicase family and contains two chromodomains, one ATP-binding helicase domain and one SLCterminal helicase domain. The CHD family of proteins are ATP-dependent chromatin remodeling enzymes which combine chromodomains with SWI2/Snf2 ATPase/helicase motifs and DNA-binding capability. Chromodomains are protein regions of about 40-50 amino acid residues found in proteins associated with chromatin remodeling and manipulation. The domain is highly conserved among both plants and animals and is found in a large variety of proteins from many genomes.
Function:
Probable transcription regulator.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
Q8TD26
Gene ID:
84181
Database links:
Entrez Gene: 84181 Human
SwissProt: Q8TD26 Human
Unigene: 371979 Human
Unigene: 644112 Human
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