This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Function:
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
Subcellular Location:
Nucleus.
Similarity:
Contains 1 fork-head DNA-binding domain.
SWISS:
O00409
Gene ID:
1112
Database links:
Entrez Gene: 1112 Human
Entrez Gene: 71375 Mouse
Entrez Gene: 314374 Rat
Omim: 602628 Human
SwissProt: O00409 Human
SwissProt: Q499D0 Mouse
Unigene: 434286 Human
Unigene: 621371 Human
Unigene: 341972 Mouse
Unigene: 392143 Mouse
Unigene: 448530 Mouse
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