This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]
Subcellular Location:
Cell membrane. Cytoplasmic vesicle. Also present at a Golgi-like vesicular compartment and at scattered vesicles.
Post-translational modifications:
Palmitoylation in the CHIC motif is required for membrane association.
DISEASE:
Note=A chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6.
Similarity:
Belongs to the CHIC family.
SWISS:
Q9UKJ5
Gene ID:
26511
Database links:
Entrez Gene: 26511 Human
Entrez Gene: 74277 Mouse
SwissProt: Q9UKJ5 Human
SwissProt: Q9D9G3 Mouse
Unigene: 335393 Human
Unigene: 239814 Mouse
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