The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP7 is an ESCRT-III-related protein that associates with CHMP4B. CHMP7 contains an SNF7 domain in the SLCterminus and is most similar to CHMP6. CHMP7 also binds to the microtubule interacting and transport (MIT) domain of the deubiquitinating enzyme, UBPY. The overexpression of CHMP7 inhibits EGFR degradation.
Function:
CHMP7 plays a role in the endosomal sorting pathway and is a component of the ESCRT III complex.
Subunit:
Interacts with CHMP4B, but not with VPS25.
Subcellular Location:
Cytoplasm. Note: Diffused localization, with some punctate distribution, especially in the perinuclear area
Similarity:
Belongs to the SNF7 family.
SWISS:
Q8WUX9
Gene ID:
91782
Database links:
Entrez Gene: 91782 Human
Omim: 611130 Human
SwissProt: Q8WUX9 Human
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