This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.
Tissue Specificity:
Pancreas.
DISEASE:
Variations in CTRC influence susceptibility to chronic pancreatitis [MIM:167800]. Chronic pancreatitis is a persistent inflammatory disorder characterized by permanent destruction of the pancreatic parenchyma.
Similarity:
Belongs to the peptidase S1 family. Elastase subfamily.
Contains 1 peptidase S1 domain.
SWISS:
Q99895
Gene ID:
11330
Database links:
Entrez Gene: 11330 Human
Entrez Gene: 76701 Mouse
Omim: 601405 Human
SwissProt: Q99895 Human
SwissProt: Q3SYP2 Mouse
Unigene: 631869 Human
Unigene: 88471 Mouse
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