CIP29 is a 210 amino acid nuclear protein whose expression is upregulated by erythropoietin. Induction of CIP2 expression is associated with cell cycle progression and apoptosis. This transcription factor binds both single stranded (ss) and double stranded (ds) DNA, though it has higher affinity for ssDNA. CIP29 is expressed at low levels in pancreas, spleen, testis, liver, kidney, heart and thymus, and is found to be expressed at higher levels in pancreatic adenocarcinoma and hepatocellular carcinoma. A translocation t(11;12)(q23;q13) in acute myelomonocytic leukemia results in the coding region of CIP29 gene fused to exon 9 of the MLL gene, which encodes for a protein with the N-terminal SAP domain and two SLCterminal nuclear localization signals of CIP29 and N-termial AT hooks and central DNA methyltransferase homology region of MLL.
Function:
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.
Subcellular Location:
Nucleus.
Tissue Specificity:
Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.
Similarity:
Contains 1 SAP domain.
SWISS:
P82979
Gene ID:
84324
Database links:
Entrez Gene: 84324 Human
Entrez Gene: 732539 Cow
Entrez Gene: 66118 Mouse
Entrez Gene: 362819 Rat
Omim: 610049 Human
SwissProt: P82979 Human
SwissProt: Q9D1J3 Mouse
SwissProt: Q498U4 Rat
Unigene: 505676 Human
Unigene: 351579 Mouse
Unigene: 1506 Rat
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