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Rabbit Anti-Constitutive androstane receptor antibody
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm; cytoskeleton. Recruited to the cytoplasm by DNAJC7.
Tissue Specificity:
Predominantly expressed in liver.
Post-translational modifications:
Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
SWISS:
Q14994
Gene ID:
9970
Database links:
Entrez Gene: 9970 Human
Entrez Gene: 12355 Mouse
Entrez Gene: 65035 Rat
Omim: 603881 Human
SwissProt: Q14994 Human
SwissProt: O35627 Mouse
SwissProt: Q9QUS1 Rat
Unigene: 349642 Human
Unigene: 486506 Mouse
Unigene: 163229 Rat
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