The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
Subcellular Location:
Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Similarity:
Belongs to the COPG family.
Contains 6 HEAT repeats.
SWISS:
Q9USF2
Gene ID:
26958
Database links:
Entrez Gene: 26958 Human
Entrez Gene: 54160 Mouse
Entrez Gene: 58847 Rat
Omim: 604355 Human
SwissProt: Q9USF2 Human
SwissProt: Q9QXK3 Mouse
Unigene: 6421 Human
Unigene: 381860 Mouse
Unigene: 39896 Mouse
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