This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the SLCterminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Function:
Essential component of the SHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The SHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the SHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome.
Subcellular Location:
Nucleus. Upon infection by HSSLV1, it is partially translocated into the cytoplasm in an HSSLV1-dependent manner.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Phosphorylated by HSSLV1 protein kinases in case of infection.
Similarity:
Belongs to the CoREST family.
Contains 1 ELM2 domain.
Contains 2 SANT domains.
SWISS:
Q9UKL0
Gene ID:
23186
Database links:
Entrez Gene: 23186 Human
Entrez Gene: 217864 Mouse
Omim: 607675 Human
SwissProt: Q9UKL0 Human
SwissProt: Q8CFE3 Mouse
Unigene: 510521 Human
Unigene: 4768 Mouse
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