In mammals, the CoREST complex is a chromatin-modifying structure that, through interactions with NRSF (neuron restrictive silencer factor), regulates neuronal gene expression and neuronal cell fate. RCOR2 (REST corepressor 2) and RCOR3 (REST corepressor 3) are nuclear proteins that each contain one ELM2 domain and two SANT domains. RCOR2 and RCOR3, both members of the CoREST family, are thought to function as components of the CoREST complex; possibly playing a role in the transcriptional repression of neuronal genes. Additionally, RCOR2 and RCOR3, in conjunction with CoREST, can form immunocomplexes with a variety of histone-modifying genes, including G9a and HDAC1. Via these protein complexes, RCOR2 and RCOR3 can further regulate transcription by controlling the methylation and demethylation of target genes during early development. While RCOR2 is expressed as only one known isoform, RCOR3 exists as two isoforms due to alternative splicing events.
Function:
May act as a component of a corepressor complex that represses transcription.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the CoREST family.
Contains 1 ELM2 domain.
Contains 2 SANT domains.
SWISS:
Q8IZ40
Gene ID:
283248
Database links:
Entrez Gene: 283248 Human
Entrez Gene: 104383 Mouse
Entrez Gene: 305811 Rat
Entrez Gene: 498485 Rat
SwissProt: Q8IZ40 Human
SwissProt: Q8C796 Mouse
SwissProt: Q5FWT8 Rat
Unigene: 98788 Human
Unigene: 283859 Mouse
Unigene: 110225 Rat
Unigene: 209048 Rat
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