Rabbit Anti-phospho-Cortactin (Tyr421) antibody

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Cortactin (phospho Y421); p-Cortactin (phospho Y421); Amplaxin; CTTN; EMS 1; EMS1; FLJ34459; Mammary tumor and squamous cell carcinoma associated; Oncogene EMS1; p80/85 src substrate; Src substrate cortactin; SRC8_HUMAN.

Cat:

SL1800R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr421:PV(p-Y)ED

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Function:
Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.

Post-translational modifications:
Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

Similarity:
Contains 7 cortactin repeats.
Contains 1 SH3 domain.

SWISS:
Q14247

Gene ID:
2017

Database links:

Entrez Gene: 2017 Human

Entrez Gene: 13043 Mouse

Entrez Gene: 60465 Rat

GenBank: NM_138565 Human

GenBank: NM_007803 Mouse

Omim: 164765 Human

SwissProt: Q14247 Human

SwissProt: Q60598 Mouse

Unigene: 596164 Human

Unigene: 205601 Mouse

Unigene: 107869 Rat

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