This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Subcellular Location:
Cytoplasmic.
Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family.
SWISS:
P07327
Gene ID:
124
Database links:
Entrez Gene: 124 Human
Entrez Gene: 11522 Mouse
Entrez Gene: 24172 Rat
SwissProt: P07327 Human
SwissProt: P00329 Mouse
SwissProt: P06757 Rat
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