Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Location:
Mitochondrion inner membrane.
Similarity:
Belongs to the cytochrome c oxidase VIIc family.
SWISS:
P15954
Gene ID:
1350
Database links:
Entrez Gene: 1350 Human
Entrez Gene: 12867 Mouse
Entrez Gene: 100188937 Rat
Omim: 603774 Human
SwissProt: P15954 Human
SwissProt: P17665 Mouse
SwissProt: P80432 Rat
Unigene: 430075 Human
Unigene: 378898 Mouse
Unigene: 105968 Rat
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