Rabbit Anti-CPAMD8 antibody

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C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; CPMD8_HUMAN; K CAP; VIP.

Cat:

SL14018R

Species Reactivity：

(predicted: Human,Dog,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human CPAMD8:51-200/1885

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]

Function:
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine.

Subcellular Location:
Secreted. Cell membrane.

Post-translational modifications:
Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.

Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Contains 1 Kazal-like domain.

SWISS:
Q8IZJ3

Gene ID:
27151

Database links:

Entrez Gene: 27151 Human

Omim: 608841 Human

SwissProt: Q8IZJ3 Human

Unigene: 631644 Human

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