This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013].
（L-Pyroglutamyl-L-histidyl-L-prolinamide）pGlu-His-Pro Amide,
C18H26N6O6
Function:
Thyrotropin releasing hormone (TRH) is a tripeptide hormone that stimulates the release of thyroid stimulating hormone and prolactin by the anterior pituitary. TRH is produced by the hypothalamus and travels across the median eminence to the pituitary via the hypophyseal portal system. In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets.
Subcellular Location:
Secreted.
Tissue Specificity:
Hypothalamus. Expressed in the hair follicle epithelium (at protein level).
Similarity:
Belongs to the TRH family.
SWISS:
P20396
Gene ID:
1440
Database links:
Entrez Gene: 1440 Human
Entrez Gene: 22044 Mouse
Entrez Gene: 25569 Rat
Omim: 275120 Human
SwissProt: P20396 Human
SwissProt: Q62361 Mouse
SwissProt: P01150 Rat
Unigene: 1363 Mouse
Unigene: 22 Rat
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