Copine 3 is a member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Copine 3 is ubiquitously expressed and contains two N-terminal C2 domains and one SLCterminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine 3 functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner. Differing from other members of the copine family, copine 3 may possess some intrinsic kinase activity. Copine 3 exists as a monomer in the cytosol and undergoes a conformational change upon binding to calcium.
Function:
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated on serine and threonine residues.
Similarity:
Belongs to the copine family.
Contains 2 C2 domains.
Contains 1 VWFA domain.
SWISS:
O75131
Gene ID:
8895
Database links:
Entrez Gene: 8895 Human
Entrez Gene: 615304 Cow
Entrez Gene: 70568 Mouse
Omim: 604207 Human
SwissProt: O75131 Human
SwissProt: Q8BT60 Mouse
Unigene: 191219 Human
Unigene: 38390 Mouse
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